Investigating the genetics of stuttering

The International Stuttering Project (ISP) represents a global collaboration. Formed in 2020, the ISP continues to collate global outbred populations of people who stutter, specifically to illuminate genetic etiology and broaden investigations of its diverse and variable phenotype. We are continually recruiting study participants. Please contact us if you would like to participate in our investigations either as a patient or research collaborator!

 

Our efforts in Australia have been featured on Today Tonight:

Meet Our Team

  • Robin M. Jones, CCC-SLP, Ph.D

    Dr. Jones is an assistant professor in the Department of Hearing and Speech Sciences in the Vanderbilt University school of Medicine in Nashville, TN, USA. His primary research interests include investigating the emotional, cognitive, and linguistic contributions to childhood stuttering as well as stuttering treatments.

    https://medschool.vanderbilt.edu/hearing-speech/person/robin-jones/

  • Janet Beilby, M.Sc., Ph.D

    Dr. Beilby is a renowned Senior Lecturer and Clinical Educator at Curtin University in Western Australia and has been a lecturer, researcher and clinician in the field of stuttering, dementia, and virtual reality for over 30 years. Dr. Beilby has treated thousands of clients, trained hundreds of students and been awarded over half a million dollars in research funds investigating varying aspects of stuttering disorders.

  • Dr. Jennifer (Piper) Below

    Associate Professor of Medicine, Genetic Medicine, Vanderbilt University Medical Center

    Dr. Below is an associate professor in the Division of Genetic Medicine at Vanderbilt University Medical Center and a 2020 Chancellor Faculty Fellow. She completed a BS in Mathematics at Carleton College in Minnesota, a PhD in Human Genetics at the University of Chicago, and her Postdoctoral Fellowship at the University of Washington in the Department of Genome Sciences. Dr. Below’s research focuses on developing novel computational methods in human genetics and discovering genes that impact health. She has developed innovative approaches to phenotyping and genetic discovery using large-scale data from DNA biobanks. She leads several large multi-institutional projects, with a focus on historically underrepresented populations and phenotypes, including a first-of-its-kind analysis of developmental stuttering. Full list of publications: https://scholar.google.com/citations?hl=en&user=XHbOHvgAAAAJ

  • Shelly Jo Kraft

    Associate Professor
    Speech Language Pathology & Audiology
    Wayne State University

    Dr. Kraft is both a practicing speech pathologist and associate professor in Speech Language Pathology and Audiology at Wayne State University in Detroit, MI, USA. Shelly Jo’s research focuses on the biological and behavioral genetics of stuttering and other communication disorders, autism, and hearing loss. She’s a dedicated lecturer, winning several outstanding teaching awards for her efforts in the classroom. Her research on stuttering has also been showcased at international conferences.

  • Jonathon Linklater, M.Sc., Ph.D

    Dr. Linklater is an independent speech and language therapist located in Dublin, Ireland. Jonathon works with both children and adults with a range of communication needs. He has been involved with the Irish Stammering Association since 2003 and established the Health Service Executive Dublin adult stuttering course in 2005. Jonathon, who stutters himself, frequently presents his therapy approach to stuttering at international conferences.

Research Publications & Grants - Have papers that are a direct result of ISP. Link to the papers

  • Identifying developmental stuttering and associated comorbidities in electronic health records and creating a phenome risk classifier.

    Pruett DG, Shaw DM, Chen HH, Petty LE, Polikowsky HG, Kraft SJ, Jones RM, Below JE. J Fluency Disord. 2021 Jun;68:105847. doi: 10.1016/j.jfludis.2021.105847. Epub 2021 Apr 15. PMID: 33894541

  • Automated Phenotyping Tool for Identifying Developmental Language Disorder Cases in Health Systems Data (APT-DLD): A New Research Algorithm for Deployment in Large-Scale Electronic Health Record Systems.

    Walters CE Jr, Nitin R, Margulis K, Boorom O, Gustavson DE, Bush CT, Davis LK, Below JE, Cox NJ, Camarata SM, Gordon RL. J Speech Lang Hear Res. 2020 Sep 15;63(9):3019-3035. doi: 10.1044/2020_JSLHR-19-00397. Epub 2020 Aug 11. PMID: 32791019

  • The Role of Effortful Control in Stuttering Severity in Children: Replication Study.

    Kraft SJ, Lowther E, Beilby J. Am J Speech Lang Pathol. 2019 Feb 21;28(1):14-28. doi: 10.1044/2018_AJSLP-17-0097. PMID: 30517950

  • Applying a Phenome Risk Classification Model to Identify Undiagnosed Developmental Stuttering Cases in a Biobank for Genome Wide Association Analysis. American Journal of Human Genetics. Under review.

    Shaw D.†, Polikowsky H.†, Pruett D.†, Chen H.H.†, Petty L.E.†, Jones R., Kraft S.J., Below J.E.

  • Multiethnic genome-wide association study of developmental stuttering. HGG Advances. Under review.

    Polikowsky H. †, Shaw D. M. †, Petty L.E. †, Linklater J., Highland H.M., Levitt B., Avery C., Mullis Harris K., Below J.E.*, Kraft S.J.*,

  • TOPsy: Psychometric validation of a novel test of speech prosody via syllable emphasis. Frontiers Neurology. In submission.

    Nayak S., Gustavson D.E., Wang Y., Jennifer E. Below J.E., Gordon R.L., Magne C.

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